Doctorate Program in Molecular Medicine and Medical Biotechnology

33° cycle-Final Examination

July 29^th, 2021

MS Teams (access code: b806z09)

Examination Committee:

Prof.ssa Viola Calabrò, Dip. di Biologia, Università degli Studi Federico II di Napoli

Prof. Alfonso Pompella, Dip. di Ricerca Traslazionale, Università degli Studi di Pisa

Prof. Giuseppe Terrazzano, Dip. di Scienze, Università degli Studi della Basilicata

8:55-9:00                         Welcome

9:00-9:20                         Emanuela Senatore

Centrosomal TBC1D31 Integrates cAMP signaling and OFD1 ubiquitylation to control Ciliogenesis

Supervisor: Antonio Feliciello

9:20-9:30                          Discussion

9:30-9:50                         Chiara Gentile

Development and characterization of an immunotherapeutic platform based on oncolytic Herpes Simplex Viruses and αCTLA-4 Antibodies

Supervisor: Nicola Zambrano

9:50-10:00                       Discussion

10:00-10:20                      Mariella Cuomo

DNA methylation dynamics at genes specific level during brain development and in schizophrenia

Supervisor: Lorenzo Chiariotti

10:20-10:30                      Discussion

10:30-10:50                      Federica Aliotta

                                       Biochemical studies of a novel class of cdc25 inhibitors

and biological analysis of the effect in melanoma cell lines

Supervisor: Maria Rosaria Ruocco

10:50-11:00                      Discussion

11:00-11:20                      Rocco Caggiano

In silico simulation of tumour cell proliferation and movement based on biochemical models of MAPK cascade

Supervisor: Giovanni Paolella

11:20-11:30                      Discussion

11:30-11:50                      Federica Carrillo

Relevance of Ncoa4 functions in tissue regeneration

Supervisor: Francesca Carlomagno

11:50-12:00                      Discussion

12:00-12:20                      Clorinda Fusco

Preferential accumulation of Foxp3e2+ Regulatory T cells with highly immunosuppressive phenotype in breast cancer subjects

Supervisor: Giuseppe Matarese

12:20-12:30                      Discussion

Break

14:00-14:20                      Angela Flavia Serpico

Mitotic spindle assembly relies on localized control of Cdk1 activity

Supervisor: Domenico Grieco

14:20-14:30                      Discussion

14:30-14:50                      Carmen Caiazza

Knock-out of STING causes impairment of antigen presentation and abolishes STAT1 activation in mouse macrophages

Supervisor: Massimo Mallardo

14:50 -15:00                     Discussion

15:00-15:20                      Francesca Gorini

Oxidative DNA damage associates with transcription and/orreplication processes

Supervisor: Stefano Amente

15:20-15:30                      Discussion

15:30-15:50                      Domenica Borzacchiello

Metabolic control of tumor growth by mitochondrial a-kinase anchor protein 1 (AKAP1)

Supervisor: Antonio Feliciello

15:50-16:00                      Discussion

16:00-17:00                      Evaluation & Announcement of examination results