Doctorate Program in Molecular Medicine and Medical Biotechnology

34° cycle-Final Examination

May 6^th, 2022

-Classrooom A- Bldg 1-

Examination Committee:

Prof.ssa Monica Dentice           Dip. di Medicina Clinica e Chirurgia, Università degli Studi Federico II di Napoli

Prof. Giuseppe Terrazzano       Dip. di Scienze, Università degli Studi della Basilicata

Prof. Francesco Trapasso         Dip. di Medicina Sperimentale e Clinica (DMSC), Università di Catanzaro

Welcome (8:55-9:00)

9:00-9:20                         Daniela Criscuolo

Role of metabolic reprogramming in the development of ovarian cancer platinum resistance

Supervisor: Franca Esposito

9:20-9:30                          Discussion

9:30-9:50                         Iolanda Scognamiglio

The relevance of exosomal microRNAs in the re-education of stromal fibroblasts: a framework for the comprehension of triple negative breast cancer

Supervisor: Gerolama Condorelli

9:50-10:00                       Discussion

10:00-10:20                      Maria Vitale

Oncolytic adenoviral vector-mediated expression of an anti-PD-L1 scFv improves anti-tumoral efficacy in a melanoma mouse model

Supervisor: Lucio Pastore

10:20-10:30                      Discussion

10:30-10:50                      Arianna Pastore

                                       ZNF224 is a mediator of TGF-β pro-oncogenic function in melanoma

Supervisor: Paola Costanzo

10:50-11:00                      Discussion

11:00-11:20                      Martina Tufano

The role of FKBP51 in the activation of Akt oncogenic pathway

Supervisor: Maria Fiammetta Romano

11:20-11:30                      Discussion

11:30-11:50                      Silvia Trombetti

Exploring the leukemogenic potential of GATA-1S, the shorter isoform of the hematopoietic transcriptional factor GATA-1, through mechanisms of mitochondrial remodeling, metabolic rewiring and apoptosis resistance associated with modulation of the cellular redox state

Supervisor: Michela Grosso

11:50-12:00                      Discussion

Break (12:00-13:00)

13:00-13:20                      Matteo Esposito

Investigating the role of Klhl14 in thyroid differentiation

Supervisor: Gabriella De Vita

13:20-13:30                      Discussion

13:30-13:50                      Cinzia Vetrei

Combinatorial approaches based on novel human immunomodulatory antibodies and aptamers for safe cancer therapy

Supervisor: Claudia De Lorenzo

13:50-14:00                      Discussion

14:00-14:20                      Lingzhi Zhang

Identification of Proteolysis Targeting Chimeras for TPM3-TrkA oncoprotein

Supervisor: Massimo Santoro

14:20-14:30                      Discussion

14:30-14:50                      Valeria Valente

Unraveling the role of HIPK2 in neurodegeneration and pathogenesis of TDP-43-related ALS disease

Supervisor: Giovanna Maria Pierantoni

14:50 -15:00                     Discussion

15:00-15:20                      Cristina Terlizzi

Modulation of glucose metabolism in oncogene-driven tumors: implications for therapy

Supervisor: Silvana Del Vecchio

15:20-15:30                      Discussion

Evaluation & Announcement of examination results (15:30-16:30)